Annualy, about 5,000 tankers are sailing across the Adriatic Sea to its northern part where they unload 70 million tonnes of oil in the port of Trieste, Koper, Venice and Rijeka. The highest density of traffic is precisely generated in the northern part of the Adriatic, which means that ships entering the Adriatic, sail towards these ports by forming a major longitudinal waterway, which is also the shortest route. Given the density of maritime traffic in the Adriatic, the greatest risk of collisions occurs at places where the main longitudinal waterways intersect with the transverse. In the case of such major incidents, it is certain that the consequences would be disastrous in the context of pollution of the environment but also of material losses. The aim of this paper is to use computer simulation of the collision of two ships, which results in a spill of 6000 tons of oil in the central Adriatic, and to show possible scenarios and ways to intervene in the spill. The obtained simulation results will compare and show the most suitable way of handling the available equipment and vessels for pollution prevention